In standard clinical settings, DNA microarrays are currently unsuitable for routine use. Prognostic classification on formalin-fixed paraffin-embedded tissues is required. In this study, we looked for new molecular markers for identifying the prognosis of gastric cancer patients.

This study, performed by a team led by Professor Zhong-Sheng Zhao, is described in a research article published in the World Journal of Gastroenterology.

The team identified that syndecan-1, E-cadherin and integrins highly correlated with each other as intracellular adhesion molecular complexes. We suggest the results of co-examination of them can be important indexes for the prognosis of gastric carcinoma. In the view of the authors, to date no clear mechanism has been found to explain the interaction of the three molecules, and no clinical research has been done to verify the findings.

Traditional clinicopathologic factors and several interesting molecules, including cell cycle regulation factors such as p27 or cyclin E, cell adhesion molecules such as E-cadherin, angiogenic factors such as vascular endothelial growth factor and placenta growth factor, oncogenes such as c-erbB2 and c-myc, and tumor suppressor genes such as p53, have been reported to correlate to the prognosis of gastric cancer patients. Cell adhesion is one of important steps in the multi-step process of gastric cancer pathogenesis.

Further research should collect more samples and emphasize the importance of studying multiple genetic alterations in concert.

编译：

在标准的临床环境中，DNA序列检测不适合用作（常规检测方法来）预测胃癌。在对由福尔马林固定-石蜡包埋的组织的预测分类是必须的。在本项研究中，我们渴望得到新的能够辨别和预知患者胃癌（发生）的分子技术。

这项由赵中生教授领导的研究的论文被发表在世界胃肠病学杂志。

研究小组鉴别syndecan-1、E-cadherin和integrins这几种高度关联的因子，其关系就像细胞内粘连分子络合物。他们认为他们之间相互试验的结果能够检索并预测出胃癌的发生。在作者的观点中，到现在为止还未能解释这三种因子相互作用的机理，同时未有任何临床研究证实这项发现。

传统的临床病理学因子和一些有趣的因子，包括细胞周期控制因子如p27 或 cyclin E，细胞粘附分子如E-cadherin，促血管生成因子如血管内皮生长因子和胎盘生长因子，肿瘤基因如c-erbB2 和 c-myc，和肿瘤抑制基因如as p53已经被报道与胃癌病人的预测相关。细胞黏附是胃癌发病的多阶式机理中的重要一步。

进一步的研究将收集更多的样本并且强调多重遗传性变异的协调的重要性。